The therapeutic agents that target ATP-sensitive potassium channels
نویسندگان
چکیده
منابع مشابه
The therapeutic agents that target ATP-sensitive potassium channels.
ATP-sensitive potassium (K(ATP)) channels are a major drug target for the treatment of type-2 diabetes. K(ATP) channels are ubiquitously expressed and link the metabolic state to electrical excitability. In pancreatic β-cells, K(ATP) channels are crucial in the regulation of glucose-induced insulin secretion. Also, K(ATP) channels are involved in the protection against neuronal seizures and isc...
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Recent studies have shown that intracerebroventricular administration of cimetidine (CIM) induces anti-nociceptive and anti–inflammatory effects in rats. However, the underlying mechanism of CIM effect has not been determined yet. This study was planned to determine the anti-nociceptive effect of CIM (50 mg/kg, i.p.) in male mice (25-30 g, n = 80) using tail flick test. Also, the role of ATP-se...
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Sulfonylurea drugs stimulate endogenous insulin secretion by blockade of ATP-sensitive potassium channels in pancreatic beta cells. These drugs are widely used in the treatment of type 2 diabetes. However, as ATP-sensitive potassium channels also exist in cardiomyocytes and coronary and peripheral arterial vascular smooth muscle cells, sulfonylurea drug usage in theory may cause unwanted cardio...
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متن کاملEndothelial biology and ATP-sensitive potassium channels
ATP sensitive potassium (KATP) channels are metabolic sensors with channel activity promoted by decreases in ATP andnor increases in MgADP. The most studied are channels present in cardiac myocytes and pancreatic b cells but KATP currents also exist more widely in a range of tissues and organs [1,2]. The channel is a hetero-octamer comprising four sulphonylurea receptors and four pore-forming i...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2016
ISSN: 1846-9558
DOI: 10.1515/acph-2016-0006